Are there instances when you dose sodium zirconium cyclosilicate more than once daily for long term therapy for patients with end stage kidney disease and hyperkalemia?
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In which instances do you consider dosing sodium zirconium cyclosilicate more than once daily for patients with end-stage kidney disease and hyperkalemia?
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1 Answer
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Nephrology · University Of California San Francisco Medical Center At Parnassus
Answered on
Not for long-term therapy. I definitely use it more than once daily to lower serum potassium levels acutely, in patients who have clotted their access and are unable to dialyze for 1-2 days until they get decloted, etc. I would imagine that it would be safe to use long-term more than once daily except for the possible risk of hypokalemia but I don't think there is enough data yet to be sure. Clearly for acute lowering of serum potassium levels over 6 mEq/L, once daily zirconium is not enough to lower potassium levels significantly.