Are you comfortable combining relugolix with enzalutamide or abiraterone?
Current NCCN guidelines recommended not combining relugolix with these agents until more data is available.
Any drug interaction concerns or other specific considerations for the combination?
Answer from: Medical Oncologist at Academic Institution
I usually avoid these combinations. The challenge is that relugolix is not superior to other ADT methods in terms of efficacy (at least based on available data) but there are safety issues with considering these combinations. All three of these medications are substrates for similar enzymatic metabo...
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