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Topics:
Infectious Disease
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General Infectious Disease
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Gram Negative Resistance
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Antimicrobial Resistance
Are you less likely to use cefiderocol for carbapenem-resistant Gram-negative bloodstream infections based on the GAME CHANGER trial showing non-inferiority to standard-of-care antibiotics?
Paterson DL, et al., PMID 41067237
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What is the best approach to determine whether antiviral post-exposure prophylaxis for influenza is appropriate in an elderly immunocompromised patient who has been vaccinated?
Do you routinely order karius in evaluation of culture negative prosthetic valve endocarditis?
How would you manage a frail but functioning elderly patient with extensive thoracolumbar spinal fusions 4-5 years ago now presenting with copious purulent drainage from L2-L4 whose MRI shows no osteomyelitis or abscess, and who has mild pain but no systemic signs or symptoms of illness?
Do you recommend, based on current evidence, avoiding antimotility agents in patients with non-fulminant C. difficile infection who have no evidence of ileus?
How might the integration of PET/CT with traditional imaging modalities alter the clinical decision-making process for suspected CIED infections without clear generator pocket involvement?
How have the results of the BALANCE trial, which demonstrated the noninferiority of 7 days of antibiotics compared to 14 days for non-S. aureus bloodstream infections, influenced your practice?
Would you ever consider oral doxycycline for treatment of either gram-negative or gram-positive uncomplicated bacteremia?
Do you recommend immunomodulating treatments such as steroids or IVIG for West Nile Virus neuroinvasive disease?
