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Are you routinely using neoadjuvant cemiplimab for cutaneous squamous cell carcinoma of any site?

Majority of patients on the seminal trial (Gross et al., PMID 36094839) had tumors isolated to head & neck, what was the rationale for this?
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For what disease sites will you consider use of neoadjuvant cemiplimab in resectable CSCC?

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4 Answers
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Radiation Oncology · University of Florida
Answered on

No

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Medical Oncology · Moores Cancer Center at UC San Diego Health
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Cutaneous squamous cell carcinoma (CSCC) most often arises in sun-exposed areas such as the head and neck regions. While surgical excision in these areas may be technically feasible, they may also be associated with cosmetic disfigurement, impaired function, and inadequate oncologic control. Most CS...

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Medical Oncology · The Ohio State University Comprehensive Cancer Center
Answered on

Patients with such cancer are usually referred to surgeons or dermatologists first. Through recent multidisciplinary conferences, we are now slowly switching treatment to a systemic neoadjuvant approach, more specifically with cemiplimab.

Rationale for this study: I am quoting the introduction of the...

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Medical Oncology · Rogel Cancer Center/University of Michigan
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As mentioned before, we are selectively using 'neoadjuvant' cemiplimab. More commonly, patients start therapy for unresectable disease, have a deep response, and we occasionally consider consolidative surgery when they achieve maximal response. This same paradigm is used for cutaneous squamous cell ...

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