Are you using NAC in lieu of hypertonic saline amidst the current shortage of hypertonic saline in patients with either CF or non-CF bronchiectasis?

The Mogayzel and colleagues guidelines for maintenance of lung health do not recommend for or against NAC in the treatment of CF Lung disease. In contrast, they do recommend the chronic use of HTS.

Mogayzel Jr et al., PMID 23540878

In CF and Non-CF bronchiectasis, my first choice is inhaled hypertonic saline. The shortage has been a challenge. I ask my patients to call local pharmacies to see if there is availability at a local pharmacy. I have them ask for 3%, 6%, or 7%. If that is unsuccessful,...