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Aside from adrenal insufficiency and thyroid toxicities, how do you approach other hormonal imbalances during treatment with immune checkpoint inhibitors?

Have you encountered changes in prolactin, testosterone, etc?
1 Answer
Mednet Member
Mednet MemberInvited Expert
Endocrinology · University of Missouri School of Medicine
Answered on

A systematic review (Barroso-Sousa et al., PMID 28973656) indicated that hypophysitis can occur in 3.2% of patients treated with ipilimumab (Yervoy) and this increased to 6.4% when combined with nivolumab (Opdivo). Obviously, adrenal and thyroid functions need to be assessed first but other function...

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