At what level of bone marrow disease would you agree to proceed with transplant for a patient with refractory AML?

Most transplant centers will settle on 5% or fewer blasts by morphology or flow cytometry as the cutoff for transplant. Exceptions or leeway is sometimes given for those undergoing myeloablative/full-intensity conditioning, and those with primary refractory disease. MRD typically refers to disease that is detectable in patients who are in morphologic remission. By definition, they would have fewer than 5% blasts. If a patient has aplasia or is hypoplastic after AML treatment, quickly proceeding ...