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At what serum sodium level do you stop desmopressin when using a clamp strategy to prevent overcorrection in hyponatremia?

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Mednet Member
Mednet Member
Nephrology · UCLA

There is no universally accepted serum sodium threshold above which DDAVP should be stopped. If there is a concern for over-rapid correction of the serum sodium level by more than 8 mmol/L in 24 hours, then DDAVP should be continued. Therefore, urinary output and urine osmolality should be monitored...

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Mednet Member
Mednet Member
Nephrology · UCSF Health

Excerpted from Verbalis et al.:

Alternatively, rather than waiting for an unwelcome aquaresis in patients with potentially reversible causes of hyponatremia, one group has advocated preemptive administration of desmopressin every 6-8 hours in combination with a slow infusion of 3% saline titrated to ...

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