Based on new data from ASCO2019, would you consider gefitinib +chemotherapy instead of osimertinib frontline for EGFRm metastatic NSCLC pts?

While gefitinib + chemo did show a similar PFS as frontline osimertinib, the tolerability and safety profile concerns me. Therefore, I do not plan to change my practice and will still use osimertinib as frontline therapy for my patients with EGFR mutated stage IV lung cancer.

There are now 2 trials (one from Japan and one from India) that report the addition of carboplatin plus pemetrexed to gefitinib improves overall survival compared with gefitinib alone in patients with stage IV EGFR mutated non-small cell lung cancer. For patients who receive their medical care in co...

No. Gefitinib is no longer the standard of care for first line EGFR mutant disease. Osimertinib has significantly better outcomes and less toxicity than either gefitinib or gefitinib plus chemotherapy, and prevents the emergence of brain metastases.

In the mednet poll most providers voted for Osimertinib as the preferred front line which is currently the standard of care in USA, and it makes sense to continue this practice since it is definitely a better drug and has CNS penetration as the experts indicate above.

Interestingly, a parallel poll ...