Can defibrotide be given safely for VOD in patients with refractory thrombocytopenia to platelet transfusions?
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1 Answers
Mednet Member
Pediatric Hematology/Oncology · Kapiolani Medical Center For Women & Children
The short answer is "yes."
The slightly longer answer is: “Yes, and in patients with veno-occlusive disease (VOD), the use of defibrotide is potentially life-saving (Richardson et al., PMID 26825712).” In the cited study, which led to its FDA approval for this indication, there was no significant dif...