Can denosumab be given every 3 months?
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1 Answers
Mednet Member
Medical Oncology · H Lee Moffitt Cancer Center, University of South Florida
Not without data. The long half life and persistence of bisphosphonates in the bone is different from the shorter half life of monoclonal antibodies targeting RANK ligand (32 days). So dosing denosumab 120mg every 3 months would probably lead to suboptimal drug levels and increased bone turnover. Wh...