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Can Droxidopa be used for augmenting orthostatic hypotension treatment in patients who are already on midodrine and/or fludrocortisone?

Is there an approach to tapering the other two medications while uptitrating Droxidopa dosing to reduce the risk of supine hypertension?
1 Answer
Mednet Member
Mednet MemberInvited Expert
Cardiology · Vanderbilt Heart And Vascular Institute
Answered on

I routinely combine droxidopa with fludrocortisone just as I would midodrine and fludrocortisone when orthostatic hypotension is refractory to tolerated doses of monotherapy.

The use of droxidopa and midodrine is something I do less commonly, or frankly just rarely. They compete for the same recept...

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