Can JAK inhibitors for established rheumatoid arthritis be continued when starting an immune checkpoint inhibitor?

The concern for Jak inhibitors is not whether JAK inhibitors treat immune-related adverse events (irAEs). The issue with JAK inhibitors is that it may allow the tumors to grow. Oncologists are split over this issue and the answer may change depending on the cancer. There are case reports on JAK inhibitors for irAEs that work. I am sure they will improve all immune toxicities. There is a French study using Jakafi & Orecnia for ICI-Myocarditis with good success. Hopefully, in time, with more studi...

Couldn't agree with this answer more. Given the paucity of evidence on the safety of continuing JAKi in this setting, would consider switching the DMARD to an alternative.

If immunomodulating DMARDs such as hydroxychloroquine and/or sulfasalazine are not options, can consider interleukin 6 axis inhibitors may be an option to consider as some research has shown that these agents may have benefits against cancer as well (Hailemichael et al., PMID 35537412). In addition, IL6Ri is being studied in co...