Can you safely use a cephalosporin in a patient who previously developed acute interstitial nephritis to amoxicillin?
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Would you use a cephalosporin in a patient who previously developed acute interstitial nephritis to amoxicillin?
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2 Answers
Mednet Member
Infectious Disease · Scott County Health Department
Answered on
Amoxicillin-associated interstitial nephritis is most often a type IV hypersensitivity reaction. Cross-reactivity with other beta-lactams is possible but poorly studied. I would try hard to find an alternative.
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Mednet Member
Allergy & Immunology · Asthma And Allergy Center
Answered on
It is not an allergic reaction. The nephritis is triggered by the crystallization of amoxicillin in the renal tubules.
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