Can you safely use a cephalosporin in a patient who previously developed acute interstitial nephritis to amoxicillin?

Amoxicillin-associated interstitial nephritis is most often a type IV hypersensitivity reaction. Cross-reactivity with other beta-lactams is possible but poorly studied. I would try hard to find an alternative.

It is not an allergic reaction. The nephritis is triggered by the crystallization of amoxicillin in the renal tubules.