Geriatric Medicine

Osteoporosis

Questions discussed in this category

What are the clinical prompts that lead you to consider deprescribing bisphosphonate therapy in older adults with osteoporosis?

1 Answer available

Do you recommend vitamin K2 supplements in patients with osteoporosis?

1 Answer available

How do you approach decision-making around initiation of osteoporosis therapy in patients with advanced dementia?

1 Answer available

How soon after a fracture would it be safe to start anti-resorptive therapy?

3 Answers available

What patient factors are most important when considering who needs a broader workup for osteoporosis prior to starting therapy?

Do you routinely rule out secondary causes of osteoporosis (i.e., TSH) in all patients prior to starting therapy? If you work up all patients, what la...

1 Answer available

What is your approach to bisphosphonate use in patients with advanced chronic kidney disease and osteoporosis?

3 Answers available

What are some practical tips in distinguishing between metabolic bone disease due to chronic kidney disease and osteoporosis?

1 Answer available

When stopping denosumab and transitioning to PO bisphosphonate, do you wait for 6 months after the last denosumab injection to start PO bisphosphonate?

2 Answers available

What is the next best osteoporosis treatment option for patients who completed 2 years of teriparatide, but has contraindication to bisphosphosnate therapy (e.g. history of atypical femur fracture)?

1 Answer available

Would you use a parathyroid hormone analog for treatment of osteoporosis in a patient with mildly elevated AlkPhos of unclear etiology?

1 Answer available

Would you start romosozumab in an active smoker?

1 Answer available

During treatment of severe osteoporosis with PTH analogs (abaloparatide), would a rise in alkaline phosphatase level >200 (in the setting of normal GGT) warrant discontinuation of medication?

There is concern for elevation in alkaline phosphatase as a precursor for bone pathology, such as an increase in risk of bone malignancy, potentially ...

1 Answer available

Papers discussed in this category

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2021 Feb 08

Safety of Oral Bisphosphonates in Moderate-to-Severe Chronic Kidney Disease: A Binational Cohort Analysis.

Current opinion in nephrology and hypertension, 2022 Jun 10

Clinical utility of bone turnover markers in patients with chronic kidney disease.

The Journal of clinical endocrinology and metabolism, 2022 Dec 17

Inpatient Zoledronic Acid and Integrated Orthopedic and Fracture Liaison Services Improve Osteoporosis Treatment Rates.

J Bone Miner Res, 2024 Aug 21

Zoledronic acid for hip fracture during initial hospitalization.

J Clin Endocrinol Metab, 2023 Oct 18

Safety of Inpatient Zoledronic Acid in the Immediate Postfracture Setting.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2025 Mar 09

Denosumab discontinuation in the clinic: implications of rebound bone turnover and emerging strategies to prevent bone loss and fractures.

JAMA internal medicine, 2022 Jan 01

Time to Benefit of Bisphosphonate Therapy for the Prevention of Fractures Among Postmenopausal Women With Osteoporosis: A Meta-analysis of Randomized Clinical Trials.

Annals of internal medicine, 2023 Jan 03

Effectiveness and Safety of Treatments to Prevent Fractures in People With Low Bone Mass or Primary Osteoporosis: A Living Systematic Review and Network Meta-analysis for the American College of Physicians.

Nutrition (Burbank, Los Angeles County, Calif.), 2001-04

Japanese fermented soybean food as the major determinant of the large geographic difference in circulating levels of vitamin K2: possible implications for hip-fracture risk.

International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition, 2022 Aug 30

Role of vitamin K2 in bone-vascular crosstalk.

Frontiers in endocrinology, 2025 Nov 05

The effect of vitamin K2 supplementation on bone turnover biochemical markers in postmenopausal osteoporosis patients: a systematic review and meta-analysis.

Frontiers in public health, 2022 Aug 11

Efficacy of vitamin K2 in the prevention and treatment of postmenopausal osteoporosis: A systematic review and meta-analysis of randomized controlled trials.

Geriatric Medicine

Osteoporosis

Questions discussed in this category

Papers discussed in this category

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