Geriatric Medicine

Dementia

Questions discussed in this category

How do you choose among SSRIs and dosing strategies for the management of behavioral and psychological symptoms of dementia?

What factors might drive decisions for different SSRIs and/or doses?

1 Answer available

What is your approach to deprescribing cholinesterase inhibitors and/or memantine in advancing stages of dementia?

2 Answers available

What would be your approach to the consideration of the use of antiamyloid monoclonal antibodies for nonamnestic Alzheimer's disease with a positive biomarker for brain amyloid pathology?

E.g., primary progressive aphasia

2 Answers available

Would you recommend a GLP-1 agonist as an option to reduce the risk of dementia in patients with a strong family history?

Seminer et al., PMID 40193122

1 Answer available

What is your antipsychotic of choice and general titration regimen in the outpatient setting for a patient with dementia and behavioral disturbances (assuming reversible causes such as urinary retention, constipation, etc. have been addressed)?

2 Answers available

How do you approach balancing the treatment of urinary incontinence with anticholinergic medications with the use of cholinesterase inhibitors in dementia?

1 Answer available

How do you approach individualizing A1c goals in patients with dementia?

2 Answers available

How do you select between antipsychotics in the treatment of delirium refractory to nonpharmacological management in hospitalized older adults with dementia?

From a geriatrics harm-reduction standpoint, can we recommend any particulars regarding dosing or selection of therapies when used as a last resort?

1 Answer available

Do you recommend life long aspirin 81 mg daily for non-specific T2 white matter hyper-intensities on MRI brain?

7 Answers available

Papers discussed in this category

The American journal of psychiatry, 2016-05-01

Heterogeneity of Treatment Response to Citalopram for Patients With Alzheimer's Disease With Aggression or Agitation: The CitAD Randomized Clinical Trial.

The American journal of psychiatry, 2016-05-01

Effects of Citalopram on Neuropsychiatric Symptoms in Alzheimer's Dementia: Evidence From the CitAD Study.

JAMA, 2014 Feb 19

Effect of citalopram on agitation in Alzheimer disease: the CitAD randomized clinical trial.

Frontiers in aging neuroscience, 2023 Mar 03

Comparative efficacy and safety of antidepressant therapy for the agitation of dementia: A systematic review and network meta-analysis.

Journal of Alzheimer's disease : JAD, 2020

The Efficacy of Sertraline, Escitalopram, and Nicergoline in the Treatment of Depression and Apathy in Alzheimer's Disease: The Okayama Depression and Apathy Project (ODAP).

Journal of the American Geriatrics Society, 2025 Apr 28

Treatment of Inappropriate Sexual Behavior in Persons With Dementia: A Systematic Review.

Journal of the American Geriatrics Society, 2016 Mar 23

Antipsychotic Medication for Prevention and Treatment of Delirium in Hospitalized Adults: A Systematic Review and Meta-Analysis.

The Cochrane database of systematic reviews, 2018 Jun 18

Antipsychotics for treatment of delirium in hospitalised non-ICU patients.

JAMA, 2011-09-28

Efficacy and comparative effectiveness of atypical antipsychotic medications for off-label uses in adults: a systematic review and meta-analysis.

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