Hematology

Bleeding disorders

Questions discussed in this category

What is your approach to pregnant patients with type 2B von Willebrand disease, particularly when thrombocytopenia is already present?

2 Answers available

Would you consider perioperative antifibrinolytics for mild factor 7 deficiency undergoing surgery?

Factor 7 levels were previously mildly low at 20-40%, but are now normalized to >60%. No prior surgeries for comparison, but has a history of heavy...

1 Answer available

What is your preferred treatment agent for type 1 von Willebrand patients needing minor procedures if they have a history of severe hyponatremia with DDAVP?

Hyponatremia occurred despite fluid restriction. Do you favor factor replacement? Or do you continue to try DDAVP and add urea +/- salt tablets, in a...

3 Answers available

How do you approach delivery planning in patients with T1 vWD?

Do you routinely recommend a C-section over vaginal delivery? Induced vs spontaneous? If a C-section is needed, do you prefer general anesthesia over...

2 Answers available

In a patient with a bleeding disorder, how would one approach anticoagulation during active COVID infection?

Bleeding disorder such as vWD

1 Answer available

In which platelet function disorders would you consider use of Novoseven as opposed to platelet transfusion?

Are there particular clinical scenarios that would affect your decision?

1 Answer available

How would you manage a patient with acquired von Willebrand disease who requires DAPT for arterial disease?

1 Answer available

Papers discussed in this category

Haemophilia : the official journal of the World Federation of Hemophilia, 2015-01

Postpartum von Willebrand factor levels in women with and without von Willebrand disease and implications for prophylaxis.

Blood Adv,

ASH ISTH NHF WFH 2021 guidelines on the management of von Willebrand disease.

Haemophilia : the official journal of the World Federation of Hemophilia, 2011 Sep 28

Changes in the levels of factor VIII and von Willebrand factor in the puerperium.

Journal of thrombosis and haemostasis : JTH, 2026 Jan 07

Higher-Dosed Clotting Factor Prophylaxis Fails to Reduce Postpartum Hemorrhage in Women With von Willebrand Disease: Findings from the Observational PRegnancy and Inherited bleeding DisordErS study (PRIDES).

Haemophilia : the official journal of the World Federation of Hemophilia, 2014-03

Desmopressin (DDAVP) in the management of patients with congenital bleeding disorders.

Am J Hematol, 2020 Jul 6

Efficacy and safety of half-dose desmopressin for bleeding prophylaxis in bleeding disorder patients undergoing predominantly low to moderate risk invasive procedures.

Blood, 2018-03-22

How I treat type 2B von Willebrand disease.

Blood, 2008 Sep 19

Clinical and molecular predictors of thrombocytopenia and risk of bleeding in patients with von Willebrand disease type 2B: a cohort study of 67 patients.

Blood, 2018 May 17

Kruse-Jarres R, Johnsen JM. How I treat type 2B von Willebrand disease. . 2018;131(12):1292-1300.

Journal of thrombosis and haemostasis : JTH, 2022 Dec 22

Challenges in the management of women with type 2B von Willebrand disease during pregnancy and the postpartum period: evidence from literature and data from an international registry and physicians' survey-communication from the Scientific and Standardization Committees of the International Society on Thrombosis and Haemostasis.

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