Rheumatology

Complement system

Questions discussed in this category

What is your approach to monitoring a patient with SLE who has persistent hypocomplementemia on hydroxychloroquine, but clinically has resolution of cutaneous symptoms and no other internal organ manifestations of disease?

(C3 just below normal, C4 undetectable)

2 Answers available

How do you approach evaluation of hypocomplementemia in a patient with arthralgias and a history of Hodgkin's lymphoma treated in the past?

ANA and ENA negative

1 Answer available

Which patients may benefit from eculizumab in refractory APS?

2 Answers available

Papers discussed in this category

Clinical immunology (Orlando, Fla.), 2019-09

Treatment of antiphospholipid syndrome beyond anticoagulation.

Seminars in arthritis and rheumatism, 2019-08

Secondary thrombotic microangiopathy in systemic lupus erythematosus and antiphospholipid syndrome, the role of complement and use of eculizumab: Case series and review of literature.

Journal of immunology (Baltimore, Md. : 1950), 2004-08-15

Complete complement components C4A and C4B deficiencies in human kidney diseases and systemic lupus erythematosus.

Autoimmunity reviews, 2009-02

The risk of ultraviolet radiation exposure from indoor lamps in lupus erythematosus.

Lupus science & medicine, 2017

Cell-bound complement activation products in SLE.

Arthritis care & research, 2019-01

Obesity is Independently Associated With Worse Patient-Reported Outcomes in Women with Systemic Lupus Erythematosus.

Lupus, 2018-08

Less than 7 hours of sleep per night is associated with transitioning to systemic lupus erythematosus.

Arthritis Rheumatol, 2021 May 02

Association of Higher Hydroxychloroquine Blood Levels With Reduced Thrombosis Risk in Systemic Lupus Erythematosus.

Arthritis Rheum,

Low blood concentration of hydroxychloroquine is a marker for and predictor of disease exacerbations in patients with systemic lupus erythematosus.

Arthritis Rheumatol, 2020 Jan 07

Hydroxychloroquine Blood Levels Predict Hydroxychloroquine Retinopathy.

Arthritis Rheumatol, 2014 Sep

Establishment of gene copy number-specific normal ranges for serum C4 and its utility for interpretation in patients with chronically low serum C4 concentrations.

Arthritis Care Res (Hoboken), 2012 Apr

Outcomes in patients with systemic lupus erythematosus with and without a prolonged serologically active clinically quiescent period.

Lupus, 2022 Jan 23

The association between lupus serology and disease outcomes: A systematic literature review to inform the treat-to-target approach in systemic lupus erythematosus.

Arthritis Care Res (Hoboken), 2022 Dec 20

Perceived Stress and Prediction of Worse Disease Activity and Symptoms in a Multiracial, Multiethnic Systemic Lupus Erythematosus Cohort.

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