Thoracic Malignancies

BRAF+

Questions discussed in this category

What is your approach to a patient with an EGFR exon 19 mutated NSCLC who develops progression on osimertinib and repeat biopsy demonstrates the EGFR exon 19 mutation and a new BRAF V600E mutation?

1 Answer available

How would you approach metastatic NSCLC (adenocarcinoma without brain mets) with PD-L1 >50% and BRAF V600E driver mutation?

2 Answers available

For patients with BRAF V600E positive lung cancer and recent PE/DVT, is there any contraindication to BRAF/MEK inhibitor therapy?

Would you hold treatment for patients who develop PE/DVT while on BRAF-directed therapy?

1 Answer available

Would you discontinue dabrafenib/trametinib in a patient with BRAF mutant metastatic lung cancer if you see mild cardiomyopathy which could be related to the drugs?

Patient does not want chemo but is tolerating these well otherwise.

1 Answer available

Papers discussed in this category

The New England journal of medicine, 2014-11-13

Combined BRAF and MEK inhibition versus BRAF inhibition alone in melanoma.

Lancet Oncol., 2017 Sep 11

Dabrafenib plus trametinib in patients with previously untreated BRAF-mutant metastatic non-small-cell lung cancer: an open-label, phase 2 trial.

The New England journal of medicine, 2012-11-01

Combined BRAF and MEK inhibition in melanoma with BRAF V600 mutations.

J BUON,

Chromosome 7 deregulation in non-small cell lung carcinoma molecular landscape.

Br J Cancer, 2019 Sep 30

Resistance mechanisms to osimertinib in EGFR-mutated non-small cell lung cancer.

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