For patients with BRAF V600E positive lung cancer and recent PE/DVT, is there any contraindication to BRAF/MEK inhibitor therapy?
Would you hold treatment for patients who develop PE/DVT while on BRAF-directed therapy?
Answer from: Medical Oncologist at Community Practice
This is a good question and not an uncommon clinical scenario. The first question is whether the PE/DVT is attributable to treatment with MEKi or to the underlying cancer or other provoked risk factors (surgery, limited mobility, hospitalization, etc). In the phase 2 trial of dabrafenib and trametin...
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