Endocrinology
Physician discussions on diabetes management, thyroid disorders, hormonal imbalances, and metabolic conditions.
Recent Discussions
How do you counsel patients on the likelihood of resolution of their hypertension post adrenalectomy for primary hyperaldosteronism?
Primary hyperaldosteronism is a curable cause of hypertension. Removal of an Aldosterone producing adenoma results in correction of biochemical abnormalities in almost all patients. Hypertension also improves but not in all patients. Studies have shown that "cure" of hypertension occurs in about 27-...
Would you recommend 11C-methionine PET/CT imaging for patients with persistent or recurrent Cushing’s disease after transsphenoidal surgery?
Some literature does suggest that this may be helpful in this clinical scenario. In addition to the Furnica paper you cite (Furnica et al., PMID 39873396), you may look at this review from Mark Gurnell's Cambridge group, Modern imaging in Cushing's disease.However, 11C-methionine is available only i...
How has the use of CGMs informed or improved your management of patients with pre diabetes or diabetes not on insulin?
Yes. It has led to behavior modification with diet and movement choices.
Do you recommend neuromodulation treatments with an implantable device for patients with chronic painful diabetic neuropathy who have not responded to common oral therapies such as Gabapentin and Amitriptyline?
Absolutely.I am a board-certified neurologist and pain medicine physician. By the time patients are referred to neurology, they have typically failed conservative oral or topical therapies. In this context, spinal cord stimulation represents a transformative option.Conventional oral medications usua...
Is Macrilen (macimorelin Dx) still available in the US for diagnosis of adult growth hormone deficiency (AGHD)?
No, it is not. The rights for Macrilen were returned from Novonordisk to Areterna Zentaris almost 1 year ago (May 2023), and as of now, no company is selling it. Although they communicated an anticipated re-launch with an alternate commercialization partner, I am not aware that that was accomplished...
How do you interpret the presence of GAD antibody in a middle-aged patient with diabetes when all other type 1 diabetes antibodies are absent?
It depends on patient's clinical course of diabetes, controlled on orals vs insulin, BMI, family history DM. For a brittle DM patient, high GAD titer could indicate DM1 or LADA. For stable DM patients, the recommendation is to have 2 positive antibodies to diagnose DM1.
What factors do you consider when deciding between RFA and surgery for a patient with a benign thyroid nodule causing dysphagia?
I primarily examine the risk of anesthesia/surgery and size of the biopsy-proven benign nodule when using ablation (thermal: RFA or microwave). We are still in a period where insurance companies just got a ICD9 for the procedure (RFA only) and it is not clear whether all insurance company will pay. ...
Would you stop denosumab in a patient with chronic kidney disease if they develop asymptomatic hypocalcemia after the injection?
No. Stopping denosumab leads to rebound bone resorption and loss of all gains. The hypocalcemia indicates insufficient calcium and/or calcitriol. Calcium intake should be 1,000-1,200 mg daily from food and/or supplements in divided doses with food.
Do you recommend repeat TSH testing after a patient switches from brand-name to generic levothyroxine?
Yes. Because the FDA allows for variability in generics and the fact that some patients are very sensitive to small changes in their levothyroxine dose, I do repeat TSH after a patient switches levothyroxine formulations.
Is there a role for use of GLP1 R agonist or dual agonist therapy for management of post bariatric hypoglycemia and dumping syndrome?
There is little systematically collected information in this area on which to base judgments. A case series of 5 post-bariatric surgical patients treated empirically with liraglutide described reduction of hypoglycemic events based on patient history. In an experimental study comparing several treat...