General Internal Medicine

Obstructive Lung Disease

Questions discussed in this category

Is there an upper threshold of pCO₂ that can cause symptomatic hypercapnia (e.g. AMS) despite metabolic compensation and normal pH?

1 Answer available

Do you recommend that your patients with COPD avoid gabapentin or pregabalin entirely, given the increased rate of exacerbations noted in patients on these medications?

Rahman et al., PMID 38224592

1 Answer available

Do you utilize the bronchiectasis severity index (BSI) in your approach to managing non-CF bronchiectasis?

1 Answer available

Is methacholine challenge on its way out?

1 Answer available

What is the rationale/evidence to support doing 4 puffs of albuterol vs. 2 puffs for a reversibility study?

3 Answers available

Do you diagnose obstruction by the criteria of FEV1/FVC < 70% or < LLN?

5 Answers available

Are the results of the BOREAS trial generalizable to non-white populations?

The cohort in the study was predominantly white. Do these results highlight significant disparities in COPD care?

2 Answers available

Is there a role for biologics to help patients with ABPA who are steroid responsive and have removed their allergen insult, but continue to have an elevated serum IgE and incomplete resolution of symptoms return to their baseline functional status?

1 Answer available

Is there a role for the use of biologics as steroid sparing agents in treating patients with ABPA who are intolerant to prednisone?

1 Answer available

Are you using NAC in lieu of hypertonic saline amidst the current shortage of hypertonic saline in patients with either CF or non-CF bronchiectasis?

1 Answer available

Is there a role for biologic therapies in asthma-COPD overlap syndrome with evidence of type 2 inflammation?

2 Answers available

Papers discussed in this category

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2000-04

Practice guidelines for diseases caused by Aspergillus. Infectious Diseases Society of America.

Chest, 2018 Jan 11

A Randomized Trial of Itraconazole vs Prednisolone in Acute-Stage Allergic Bronchopulmonary Aspergillosis Complicating Asthma.

J Allergy Clin Immunol Pract, 2021 Mar 06

Real-World Effectiveness of Anti-IL-5/5R Therapy in Severe Atopic Eosinophilic Asthma with Fungal Sensitization.

Chest, 2020 Aug 31

Real-World Effectiveness of Benralizumab in Severe Eosinophilic Asthma.

J Allergy Clin Immunol Pract, 2020 Jun 16

Omalizumab Is an Effective Intervention in Severe Asthma with Fungal Sensitization.

Cureus, 2020 Aug 12

Mepolizumab as Possible Treatment for Allergic Bronchopulmonary Aspergillosis: A Review of Eight Cases.

J Allergy Clin Immunol Pract, 2015 Jan 29

Clinical efficacy and immunologic effects of omalizumab in allergic bronchopulmonary aspergillosis.

American journal of respiratory and critical care medicine, 2013-04-01

Cystic fibrosis pulmonary guidelines. Chronic medications for maintenance of lung health.

The New England journal of medicine, 2025 Apr 24

Phase 3 Trial of the DPP-1 Inhibitor Brensocatib in Bronchiectasis.

Journal of asthma and allergy, 2019

Two vs four puffs of albuterol: does dose change bronchodilator response?

Magnetic resonance imaging clinics of North America, 2009 May

Arterial spin-labeled MR perfusion imaging: clinical applications.

General Internal Medicine

Obstructive Lung Disease

Questions discussed in this category

Papers discussed in this category

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