Hospital Medicine
Physician discussions on inpatient care, transitions of care, diagnostic reasoning, and hospital-based protocols.
Recent Discussions
How do you approach conversations regarding discontinuation of transfusions in patients with advanced hematologic malignancies who are otherwise appropriate for hospice?
While not an expert in leukemia care or MDS, the answer is nuanced (both in the care of patients and to hospice agencies). Some hospice programs will make exceptions to blood transfusions depending on how frequent - so it is always good to ask. From a clinical perspective, important to consider whet...
How long do you wait before arranging AVF placement in patients with AKI who remain dialysis dependent?
About 35-45% of dialysis-requiring AKI patients discharged from the hospital on dialysis will recover sufficient renal function to stop dialysis. The majority of patients who recover kidney function do so within the first 60 days after discharge. Elderly patients and those with poor pre-AKI kidney f...
How would you plan a post-op, distal rectal adenocarcinoma s/p neo-adjuvant chemotherapy and APR with minimal treatment response?
The PROSPECT trial evaluated the omission of radiotherapy from preoperative management for cases that presented with a disease that could be resected with a sphincter-sparing TME. In addition, if the disease responded poorly to preoperative FOLFOX, then patients on that arm were required to receive ...
Do you use intrapleural tPA/dornase in loculated effusions that are not due to infection?
The use of tPA ONLY has been reported in patients with a complicated pleural fluid collection, not due to infection (Heimes et al., PMID 28616283). The dose was 6 mg in 50 mL of normal saline instilled via a pleural chest tube. However, lower doses have been used (Thomas et al., PMID 25742001).
Which biomarkers or diagnostic tools do you prioritize to support the decision to start antifungal treatment in septic patients with no clear source of infection but at high risk for fungal infections?
In general terms we do not use biomarkers to decide to start antifungals in a septic patient. We use them to confirm or rule out the infection once the antifungals were started based on clinical suspicion/presentation. BDG in particular has very good negative predictive value for candidemia, but due...
What is your strategy for managing immunosuppression in patients with a kidney transplant who develop metastatic cancer?
This is a difficult situation. I presume this question refers to cancers for which there is no option of cure. We always discuss the goals of care and review with the patient and their treating oncologist what the prognosis might be. If chemotherapy or check-point inhibitor treatment is planned we ...
What are some potential etiologies to consider for isolated, mildly elevated BNP levels with normal TTE findings in an asymptomatic, elderly patient?
BNP and pro-BNP both increase with age, especially in women, and must therefore be interpreted in that context. Pro-BNP less than 300 pg/mL indicates low likelihood for acute heart failure at all ages (though there are exceptions). The recommended age-based thresholds for diagnosing heart failure/vo...
How would you manage a patient with sickle cell disease who is infected with COVID-19?
We have limited knowledge about this management. The Sickle Cell Disease Association of America's Medical and Research Advisory Committee has issued a provider advisory. Also, Dr. Julie Paniepento has created a registry that can be viewed in real time here: https://covidsicklecell.org/ In general, t...
For pregnant patients in their first trimester presenting with acute MI with plan for emergent angiogram, who then subsequently have resolution of chest pain and EKG changes following initiation of heparin gtt, DAPT, would you still consider proceeding with LHC or treat medically with presumptive diagnosis of SCAD?
Great question and a highly debatable topic. I would consider a coronary angiogram to define the coronary anatomy as there are many differentials for pregnancy-associated acute myocardial infarction with ST elevation and treatment can differ accordingly. A conservative approach is acceptable for a l...
Would you start once-weekly tirzepatide over once daily basal insulin in a patient with Type 2 diabetes with inadequate control on oral antihyperglycemia drugs?
The issue examined in the paper cited of whether insulin or GLP-1RA is a better strategy in the setting of inadequate control of T2D was a hot question in the first part of this century but has been examined repeatedly and is now codified in global guidelines -- GLP-1RA should be used before insulin...