Hospital Medicine
Physician discussions on inpatient care, transitions of care, diagnostic reasoning, and hospital-based protocols.
Recent Discussions
Are there any non-beta-lactam antibiotic options for treatment of neurosyphilis in non-pregnant adults?
Doxycycline is a consideration. There are no conclusive data, but a few anecdotal reports are supportive -- the most recent (in a brief PubMed search) cited below. On the other hand, there is at least one case report (also cited) of a patient treated with doxycycline who subsequently re-presented wi...
How do you time PET/CT surveillance and COVID boosters?
I have not changed the timing of PET surveillance imaging around vaccinations but 1) is a frequent question from patients, and 2) I have seen a fair amount of false positive FDG avid axillary adenopathy post-vaccination. Think this tends to be too unpredictable in the duration of these imaging findi...
How reliable is an exercise stress echo in the diagnosis of exercise-induced heart failure with preserved ejection fraction?
This is my understanding of HFpEF. It is a clinical diagnosis of exertional Dyspnea in patients with risk factors such as HTN, atherosclerosis and Hyperlipidemia, increased BMI, and inactivity. A new classification means stage A only risk factors, stage B has some organ dysfunction such as LVH, left...
How long do you anticoagulate for cirrhosis patients who have portal vein thrombosis extending to the mesenteric veins?
I recommend indefinite anticoagulation for most patients with portal vein thrombosis, and at least 3-6 months if there are risk factors for bleeding. Once they complete anticoagulation for the first 6 months, I re-evaluate their risk of recurrent thrombosis vs bleeding, and if there is an underlying...
In which situations do you preferentially use an MCOT in lieu of a standard event monitor?
In most situations where the concern for "actionable" arrhythmias is low (e.g., isolated palpitations, mild lightheadedness, AF burden, PVC burden, known persistent AF for assessment of rate control, etc.), I typically would use an extended 7-14 day Holter mostly for symptom-arrhythmia correlation s...
What therapies do you routinely use to prevent mucus plug formation after endobronchial stent placement?
After airway stent placement, especially silicone stents and/or Y stents, I start my patients on albuterol neb BID; hypertonic saline neb BID, and NAC neb BID. If there are any issues with adherence, I use either albuterol + hypertonic saline or albuterol + NAC depending on patient preference. If th...
What is your approach to bridging anticoagulation in patients with history of recent HIT?
One should not re-expose patients with past HIT to heparins. Even with remote HIT, there is a high rate of serologic recurrence (eg, Warkentin and Anderson, PMID 27114458) and while the rate of overt HIT relapse may be low with proper precautions, I have seen and published a couple of fatal HIT recu...
Are the results of the BOREAS trial generalizable to non-white populations?
There is currently not enough data to conclude that the trial is generalizable to non-white population.
How would approach the management of a patient with significantly positive anticardiolopin and beta 2 glycoprotein antibodies in the absence of any clotting (including obstetric) history but with significant thrombocytopenia (but no other features of active connective tissue disease)?
I would first evaluate for other causes of thrombocytopenia (most of them can also result in positive APL antibodies): CTD, medications, liver disease, pregnancy, malignancy, splenomegaly, etc.I would not treat stable asymptomatic thrombocytopenia.If worsening/symptomatic, I would treat like any oth...
When do you consider genetic testing in patients with concern for hemiplegic migraine?
No, a good history will make the diagnosis for you!