Neurology
Expert perspectives on neurological conditions, stroke management, movement disorders, and neuromuscular disease.
Recent Discussions
How do you counsel patients on how to take abortive migraine medications during the prodrome period?
I do not routinely counsel patients to take abortive treatments during prodrome. It would depend on headache frequency. It would be hard if their headache frequency is high, such as >8-10 headache days per month, as they may run out of their abortive treatment. If they have low headache frequency an...
What level of relief do you target with acute migraine treatments before you think there is diminishing returns on trialing a different agent?
What I try to do abortively for my migraine patients is to find them a medication, currently generally a triptan or a gepant, that they tolerate without side effects and that consistently provides them with full relief of their headaches within 2 hours of treatment. Excellent tolerability is key bec...
How does osteoporosis or fracture risk affect your use of CGRP monoclonal antibodies?
As far as I know, this is a purely theoretical concern. Time will tell, and, in addition, we have very effective treatments available for osteoporosis, if this is an issue.
What treatment strategies can reduce the risk of post-concussion syndrome after an acute injury?
When evaluating a patient for their acute concussion, it is important to screen in the history for known factors that can prolong recovery if unaddressed. These include: sleep, hydration, mood issues, lack of activity for more than 48 hours, history of migraines, ADHD, anxiety, and depression. In th...
In older adults with mild cognitive impairment, do you ever prescribe cholinesterase inhibitors and/or memantine?
This is a great question, and of course, "do you ever" will get you in trouble every time! Let me start by saying that, in general, I do not prescribe these drugs for MCI. Cholinesterase inhibitors are clearly indicated for the mild-moderate stage of some kinds of dementia (some people would include...
How do you counsel patients and doctors on antibiotic avoidance in myasthenia gravis?
I generally recommend avoiding aminoglycosides and most macrolides in MG. The rationale is that there are alternative effective antibiotics for most of the infections covered by the above categories. With fluoroquinolones, however, it's not that simple, because there are some infections that are uni...
What is the role for inpatient limited-montage EEG recording?
Unequivocal YES! For purposes of detecting severe seizures that cause brain injury (i.e., high seizure burden, status epilepticus), a reduced montage EEG is more than adequate, performs equivalently, and in fact BETTER because of the Clarity AI algorithm which continuously monitors, interprets, and ...
Does receiving IVIG confound the result of SPEP and/or UPEP?
IVIG being a product of polyclonal immunoglobulins may ‘produce’ a monoclonal spike if the AUC is falsely calculated by the reader. IFE usually shows polyclonal banding but every now and then a monoclonal band is picked up. Being an IgG molecule with a 21 day halflife; and with the assumption that i...
When do you consider using general anesthesia for endovascular thrombectomy?
I perform all of my thrombectomy cases under general anesthesia. There is better hemodynamic control, no patient movement to manage, which increases procedural efficiency as a result. In moderate sedation cases, patients can feel aspiration and stent retriever passes through the vessel, which causes...
How do you approach short term antithrombotic regimen, antiplatelets or anticoagulation, after Watchman device placement in ischemic stroke patients with atrial fibrillation and cerebral amyloid angiopathy who are at high risk for intracranial hemorrhage?
This is a good question. Our group published a paper on a series of patients with CAA who underwent placement of Watchman devices for atrial fib (Schrag et al., PMID 32770310). We usually did not anticoagulate patients at all, and we saw only one very minor stroke. I think that it would also be reas...