Neurology

Gastrointestinal Cancers

Questions discussed in this category

What treatments, after appropriate dose reductions/delays, do you offer for patients with oxaliplatin-induced cold allodynia/dysesthesia?

Do medications that help with painful chemotherapy-induced sensory neuropathy also help with the cold neuropathy?

3 Answers available

How do you manage neuropathic chemotherapy agents in patients with underlying multiple sclerosis?

Are there contraindications to drugs like oxaliplatin or abraxane? Does chronicity or severity of the patient's underlying symptoms play a role in yo...

1 Answer available

How do you manage oxaliplatin-induced acute peripheral nerve hyperexcitability?

Patients can develop sensory and motor symptoms such as paresthesias, jaw/facial pain and stiffness, cramping and twitching, ptosis and vision changes...

2 Answers available

Papers discussed in this category

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2014-04-01

Phase III randomized, placebo-controlled, double-blind study of intravenous calcium and magnesium to prevent oxaliplatin-induced sensory neurotoxicity (N08CB/Alliance).

Oncol Lett, 2015 Aug 11

FOLFIRINOX-induced reversible dysarthria: A case report and review of previous cases.

ESMO open, 2023 Apr 03

A randomized controlled trial of hand/foot-cooling by hilotherapy to prevent oxaliplatin-related peripheral neuropathy in patients with malignancies of the digestive system.

JAMA, 2013-04-03

Effect of duloxetine on pain, function, and quality of life among patients with chemotherapy-induced painful peripheral neuropathy: a randomized clinical trial.

Annals of oncology : official journal of the European Society for Medical Oncology, 2014-06

Improved time to treatment failure with an intermittent oxaliplatin strategy: results of CONcePT.

J. Clin. Oncol.,

OPTIMOX1: a randomized study of FOLFOX4 or FOLFOX7 with oxaliplatin in a stop-and-Go fashion in advanced colorectal cancer--a GERCOR study.

J Clin Oncol, 2020 Jul 14

Prevention and Management of Chemotherapy-Induced Peripheral Neuropathy in Survivors of Adult Cancers: ASCO Guideline Update.

JAMA internal medicine, 2024 Sep 01

Preventive Effect of Neuromuscular Training on Chemotherapy-Induced Neuropathy: A Randomized Clinical Trial.

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2025 Mar 25

Core preoperative symptoms and patients' symptom experiences in oral cancer: a mixed-methods study.

Pain, 2020 Feb

Oxaliplatin-induced neuropathy occurs through impairment of haemoglobin proton buffering and is reversed by carbonic anhydrase inhibitors.

American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2014 Jan 01

Prevention and treatment of chemotherapy-induced peripheral neuropathy.

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