Medical Oncology
Physician insights on cancer treatment protocols, immunotherapy, targeted therapies, and clinical trial updates.
Recent Discussions
How would you approach a patient who has developed neutropenia with the combination of trastuzumab/pertuzumab in the adjuvant setting?
I have noted an increase in cytopenias IF the combo is given as Phesgo as compared to IV. I have one patient who had sign cytopenia on Phesgo and did quite well on IV.
Would you offer a complement inhibitor to a minimally symptomatic PNH patient with mild non-transfusion dependent hemolytic anemia?
The context would determine whether this patient should receive complement inhibitor. The first consideration is whether the patient has concurrent aplastic anemia or bone marrow failure. Often, patients with aplastic anemia have a small PNH clone that is not clinically significant and does not caus...
How would you treat a patient with late relapsed metastatic seminoma with only large (>10cm) pulmonary metastases and LDH nine times the upper limit of normal?
From the description, it is not really clear whether this is late relapse after initial surveillance or radiotherapy, versus relapse after chemotherapy. If the former, which is what I think you are presenting, this is a pretty unusual pattern of presentation after surveillance or radiotherapy, and...
How do you approach patients with driver mutation positive, Stage IV NSCLC who don't benefit from upfront first-line TKI?
It depends on the mutation. EGFR mutants after Osimertinib:- If oligometastatic disease: an option is radiation to the oligometastatic spots and continue osimertinib. It is important to re-biopsy as well due to the possibility of small cell transformation. If transformed to small cell, in general, c...
What is the optimal systemic therapy for dedifferentiated chondrosarcoma?
DD Chondrosarcoma typically has a low-grade cartilage component and the transformed, high-grade component often resembles UPS or osteosarcoma. So we treat these tumors a 'la osteosarcoma, acknowledging that this tends to be a disease of the elderly and appropriate dose/regimen modification will be r...
Under what circumstances would you consider anticoagulation in a young female patient with persistently elevated factor XI activity?
First, get a baseline D-dimer to see how procoagulant she is at that point. If elevated, long travel on plane, pre-op and post-op for 2 months - consider short-term anticoagulation. If past thrombosis - give lifelong anticoagulation. If pregnant - follow D-dimer; if it goes up, anticoagulate.
Which patients with mCRPC on ADT + advanced anti-AR do you treat with bisphosphonates or denosumab?
Men with bone-metastatic CRPC face a relatively high rate of fractures due to bone loss as a result of potent AR inhibition and ongoing ADT but also due to lytic and sclerotic bone metastases which create focal weakening of the bone matrix despite the pathologic bone formation. The fracture rate was...
Does concurrent brain and systemic progression alter your choice of systemic therapy for patients with metastatic SCLC with early progression on chemoimmunotherapy and WBRT?
This is a challenging situation as is expected when treating most patients with ES SCLC. If I give a patient carboplatin with etoposide and a checkpoint inhibitor and they progress shortly thereafter, the standard treatment options are limited. They include single agent chemo such as topotecan, lurb...
In addition to ADT, how would you treat Gleason 8, pure ductal prostate adenocarcinoma with oligometastatic disease?
Based on the available data and knowledge, it is difficult to answer this question definitively.Although prostate ductal adenocarcinoma (PDA), was first described more than 50 years ago and its behavior as an aggressive variant is increasingly being recognized, evidence-based management of PDA is no...
What chemotherapy backbone will you use with pembrolizumab in the neoadjuvant setting for triple negative breast cancer?
I don't have an answer to this, but just opinions. There are several decisions that we will need to make regarding how to best use immunotherapy, unfortunately without much data to guide us:1) What chemo backbone to use?2) Do we really need to continue pembro adjuvantly? If so, in whom? Everyone? On...