Pediatric Hematology/Oncology
Clinical discussions on pediatric blood disorders, childhood cancers, and specialized treatment protocols.
Recent Discussions
What neoadjuvant, adjuvant chemotherapy regimen or targeted therapy can be used in paediatric patients with pelvic peripheral medulloepithelioma?
We published this paper that may help you:Presacral Medulloepithelioma: Case Report and Literature Review.Honnorat M, Al-Karmi S, Hawkins C, Johnston D, Gerstle T, Schechter T, Huang A, Bouffet E.J Pediatr Hematol Oncol. 2020 Apr;42(3):244-247. doi: 10.1097/MPH.0000000000001460.I would be happy to s...
What is your preferred adjuvant chemotherapy for a pediatric patient less than 1 year old who had a gross total resection of a localized intracranial ependymoma, and will not be receiving radiation therapy due to his/her young age?
Based on the results of the St Jude multi-institutional clinical trial for young children with ependymoma, SJYC07, the results of which were published recently in the neuro-oncology journal, we would recommend systemic therapy with a combination of methotrexate, vincristine, cisplatin and cyclophosp...
What treatment do you offer to a pediatric patient with an optic pathway glioma with a BRAFV600E mutation who progressed despite receiving conventional chemotherapy, BRAF/MEK inhibitors, and radiation therapy?
These cases are often tough, especially in this location. I assume the patient does not have NF1? Most patients with NF1 will not have concurrent specific BRAF mutations. One alternative therapy is a combination of bevacizumab and irinotecan (published by Gururangan et al). Also, if the patient prev...
Should I wear gloves during a routine physical exam on an asymptomatic patient with no risk factors for COVID-19?
As per FAQ’s posted by ASTRO: There is no reason to do so at this time. Be vigilant re: hand hygiene and wiping down any equipment that touches the patient (stethoscope, etc.). Additionally, any equipment that touches mucosa/secretions of the patient must be sterilized (rhinolaryngoscope, etc.). For...
How do you treat late medullary relapsed B-ALL in a patient with Down Syndrome?
I have had this exact case. My patient did not tolerate (nearly died of sepsis) with the relapsed ALL COG therapy - so I used standard risk Down syndrome ALL therapy just like a newly diagnosed ALL, standard risk DS - after that, I have kept her on pseudo-maintenance (just 6MP & po MTX) for 5 years ...
What chemotherapy would you recommend for a patient with Ewing Sarcoma who has relapsed after being initially treated with vincristine/doxorubicin/ifosfamide?
If the relapse occurred less than 2 years off original chemotherapy, I would use vincristine, irinotecan, and temozolomide. If more than 2 years off, go back to the original regimen. In either case, consider ifosfamide-etoposide if failing to get a CR at the point of maximum response.
How do you determine whether to treat a young adult with stage IA Hodgkin Lymphoma with the adult or pediatric treatment paradigm?
There is a long history of pediatric protocols for HL differing somewhat from the adult ones, but not much biologic rationale to support this, as the disease in young adults is biologically the same as in pediatric patients. Side effects of RX may of course differ, particularly with regards to RT an...
Should patients with bleeding disorders increase their home supplies of clotting factors foreseeing a possible shortage of product availability due to COVID-19?
No. The Medical and Scientific Advisory Council (MASAC) for the World Federation of Hemophilia recommends against increasing the already recommended home supply of clotting factors: One month worth of regular prophylaxis doses if on a prophylactic regimen; and one major correction dose, and two mino...
Are patients with bleeding disorders receiving plasma-derived products at increased risk of acquiring COVID-19?
No. The current process of manipulation of plasma derived products eliminates SARS-Cov-2. SARS-CoV-2 is a large virus (120 nm diameter) with a lipid envelope. Therefore, it is highly susceptible to processing steps used in processing such as solvent-detergent, low pH incubation, caprylate-pasteuriza...
How do you treat a patient with a history of clinical stage IIb cN2, mixed germ cell embryonal carcinoma treated with BEP and RPLND five years ago, who now has signet ring cell adenocarcinoma with abdominal carcinomatosis with an unknown primary?
My experience would suggest that this is a second primary unrelated to his germ cell tumor. I would predict that the i12p will be negative and, if it were available, the MiR371 would be negative. I presume his current AFP and HCG are negative. I have seen this situation once with a young man almost ...