Primary Care
Physician perspectives on preventive care, chronic disease management, and evidence-based primary care practice.
Recent Discussions
Do you consider late latent syphilis adequately treated if a patient receives a 10-14 day course of IV ceftriaxone for another indication?
This is a great question and not uncommon scenario. First, I would emphasize the importance of accurately staging the patient as 'late latent' and be sure there are no current signs or symptoms concerning for neurosyphilis, ocular, or otic (even before the IV CTX was given). Having said that, the bo...
What infectious prophylaxis do you use for patients with newly diagnosed multiple myeloma?
Excellent question for sure. In order of controversial nature/lack of evidence/lack of consensus around evidence: 1) Antiviral prophylaxis - I don't think there's any controversy around this, particularly in patients on PIs and/or a CD38 mAb. We do use acyclovir even in patients who have received th...
How do you approach antidepressant choices for patients with generalized anxiety disorder when the patient reports excessive sedation on low doses of SSRIs?
We forget that bupropion, despite systemic misconceptions, has a very good anxiolytic effect. It is the darling of the centers treating refractory anxiety disorders.
How do you approach the use of metformin in the management of prediabetes for patients who are neither obese nor have a family history of diabetes?
When considering the approach to a patient with a diagnosis of pre-diabetes, I think it is important to be sure the patient actually meets criteria. Most of us screen patients at risk with A1C levels because it is so much easier. However, A1C levels do not fully correspond to glucose levels and may ...
When do you recommend using trabecular bone score (TBS) for managing osteoporosis?
Trabecular bone score is a valuable tool in the evaluation of osteoporosis and risk of fracture. It is an indirect indicator of bone microarchitecture. Although TBS predicts fracture risk, it should not be used alone but in conjunction with BMD for deciding whether to treat the osteoporosis and if s...
How do you approach follow up of young patients with isolated +ANA, but no current clinical signs or symptoms of SLE?
An old study showed that ANA can be positive in patients who develop lupus up to 9 years (average 3 years) before the onset of clinical disease but it was not necessarily isolated ANA as Ro and La antibodies could also be detected long before the onset of the disease (Arbuckle et al., PMID 14561795)...
Do you adjust the dose or the timing of levothyroxine ingestion in patients on anti-acid medications?
Actually, adjusting the timing of levothyroxine ingestion probably doesn’t help much, since the proton pump inhibitors, and other similar drugs, have a duration of action of 12–24 hours. I would recommend checking serum TSH levels after the patient has been on the gastric acid medication for 4–6 wee...
How do you approach the use of buprenorphine/naloxone in pregnant and breastfeeding patients?
If the patient is already on it, many doctors, including myself as an addiction psychiatrist, will simply switch to the same dose without the naloxone component, just to use the minimum necessary meds while pregnant. It’s not a hard and fast rule though. The dose may need titration later in pregnanc...
What treatment regime would you recommend for localized hyperhidrosis affecting the scalp that has failed topical aluminum chloride and oral glycopyrrolate?
I have personally found that oxybutinin is more effective than glycopyrrolate with fewer anticholinergic side effects.
How do you do a levodopa trial in the outpatient setting?
In a patient with Parkinsonism whom I am starting levodopa treatment for, I begin by conducting a detailed motor examination using the MDS-UPDRS III to assess baseline symptoms. Typically, bradykinesia and rigidity respond most consistently and robustly to treatment. While tremor and gait disturbanc...