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Physician perspectives on preventive care, chronic disease management, and evidence-based primary care practice.

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Do you ever use Joyrnavx in a patient with end stage liver disease?

1 Answers

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Hepatology · UCLA

I have not encountered this novel oral small molecule medication Suzetrigine for the management of acute moderate to severe pain (FDA approved indication) in my patients with cirrhosis. The drug received FDA approval in Jan 2025 after two phase III trials where it was used for pain control after b...

What is your approach to symptom management in patients with infectious diarrhea?

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General Internal Medicine · UCSF

When it comes to infectious diarrhea, I would consider a short course of loperamide for symptomatic relief, provided that my suspicion for C. diff colitis and/or dysentery is low. Antimotility agents in the setting of toxin-producing infectious diarrhea can increase the risk of toxic megacolon (in C...

What is your approach to symptom management in patients with infectious diarrhea?

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1 Answers

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General Internal Medicine · UCSF

When it comes to infectious diarrhea, I would consider a short course of loperamide for symptomatic relief, provided that my suspicion for C. diff colitis and/or dysentery is low. Antimotility agents in the setting of toxin-producing infectious diarrhea can increase the risk of toxic megacolon (in C...

What is the recommended follow-up/surveillance schedule following organ preservation treatment approach for cT1-2N0 rectal cancer?

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2 Answers

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Medical Oncology · OHSU Knight-Legacy Health Cancer Collaborative

Patients with stage I rectal cancer treated with organ preservation require close surveillance to rule out tumor regrowth and local recurrence that may be salvaged with radical surgery. The highest risk of recurrence is within 2 years after completion of neoadjuvant therapy and patients should be fo...

When do you refer patients back to their PCP for the predominant management of their medical care following completion of oncologic or BMT treatment?

1 Answers

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Pediatric Hematology/Oncology · Northwell Health

Transitions of care are always challenging, especially for patients with complex medical histories, including cancer or stem cell transplantation. There are many different models for how and when to transition patients back to primary care or shared care. The ongoing, often complex needs of survivor...

What are best practices for taking care of lung cancer patients during the COVID-19 pandemic?

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4 Answers

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Medical Oncology · Indiana University

This is a great question, and as always there is no one size fits all. For patients on active treatment for lung cancer such as chemoimmunotherapy, I continue to stress the importance of hand washing, social distancing, and to work on reducing wait times in the waiting room to limit exposure, etc. I...

What is your approach to iron supplementation in patients with an active infection?

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3 Answers

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Hospital Medicine · Yale School of Medicine/Yale-New Haven Hospital

In patients with active infections, I generally avoid intravenous iron due to the potential for promoting pathogen growth, a practice supported by cautions from nephrology and gastroenterology society guidelines. However, evidence for the risk of infection with IV iron is inconsistent, underpowered,...

What is your approach to iron supplementation in patients with an active infection?

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3 Answers

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Hospital Medicine · Yale School of Medicine/Yale-New Haven Hospital

In patients with active infections, I generally avoid intravenous iron due to the potential for promoting pathogen growth, a practice supported by cautions from nephrology and gastroenterology society guidelines. However, evidence for the risk of infection with IV iron is inconsistent, underpowered,...

Do you recommend checking anti-drug antibodies for patients on TNF inhibitors?

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Rheumatology · NYU Grossman School of Medicine

This is a very good question with direct clinical practice implications. I do not check or follow anti-drug antibodies when using TNF inhibitors for the treatment of rheumatoid arthritis or psoriatic arthritis. There are reports that suggest, on a group level, that these antibodies, if present, impa...

How do you approach the management of extremely low LDL levels in older adult patients receiving statin therapy for primary prevention of cardiovascular disease?

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1 Answers

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Cardiology · Washington University School of Medicine

In the absence of side effects, I am not concerned about very low LDL levels (e.g., less than 20 mg/dL), as there is a fairly linear association between LDL and CV risk, and there is no convincing evidence that even extremely low LDL levels are associated with cognitive impairment, intracranial hemo...