Primary Care
Physician perspectives on preventive care, chronic disease management, and evidence-based primary care practice.
Recent Discussions
How do you approach the use and interpretation of the FDA-approved plasma pTau181 blood test for Alzheimer's disease in a community-dwelling older adult with subjective cognitive complaints and a normal cognitive screen?
I follow current guidelines, which recommend against testing in those without objective cognitive impairment, given the high rate of false positives. Unless the pre-test probability is high, I would not test. That having been said, future developments (such as subQ modes of anti-amyloid Rx, greater ...
How do you approach the use and interpretation of the FDA-approved plasma pTau181 blood test for Alzheimer's disease in a community-dwelling older adult with subjective cognitive complaints and a normal cognitive screen?
I follow current guidelines, which recommend against testing in those without objective cognitive impairment, given the high rate of false positives. Unless the pre-test probability is high, I would not test. That having been said, future developments (such as subQ modes of anti-amyloid Rx, greater ...
How long do you treat retroperitoneal fibrosis with immunosuppression?
I normally treat for 9 months to a year depending on response. I have found PET CT useful in determining if there is active ongoing inflammation.
How do you manage incidentally found venous sinus thrombosis?
I would make sure first that it is not simply a congenitally small sinus. If there is truly a CVST, I would probably treat with a DOAC for 3 months and reassess with CTV.
How do you wean off of primidone in patients with essential tremors?
If a patient has been on primidone for less than one month, it can be simply discontinued in most cases. Slower withdrawal may be necessary in patients with seizures, patients on multiple other medications, or with other abnormal metabolism. For patients needing a slower taper, generally lowering th...
For transgender women patients wanting to address their voice tone, do you first refer to ENT (i.e., for consideration of tracheal shave) or to speech language pathology (i.e., for behavioral speech therapy)?
Our center for transgender medicine and surgery, one of the biggest in the country, recommends speech pathology with a person trained in feminizing voice.
For transgender women patients wanting to address their voice tone, do you first refer to ENT (i.e., for consideration of tracheal shave) or to speech language pathology (i.e., for behavioral speech therapy)?
Our center for transgender medicine and surgery, one of the biggest in the country, recommends speech pathology with a person trained in feminizing voice.
Do you frequently recommend the HPV vaccination series to patients above 26 years old?
The FDA approved the use of the 9-valent HPV vaccine in adults aged 27-45 in October 2018. In June 2019, the ACIP recommended that men and women aged 27-45 discuss vaccination with their doctor in a shared decision-making model. Extending mass vaccination for all adults aged 27-45 would cost approxi...
Do you frequently recommend the HPV vaccination series to patients above 26 years old?
The FDA approved the use of the 9-valent HPV vaccine in adults aged 27-45 in October 2018. In June 2019, the ACIP recommended that men and women aged 27-45 discuss vaccination with their doctor in a shared decision-making model. Extending mass vaccination for all adults aged 27-45 would cost approxi...
How do you approach adding colchicine to a patient who is on a stable statin regimen?
This is a good question and a tough situation, since the drug-drug interaction here can be as subtle as myalgias but as severe as rhabdomyolysis (rare but happens). If you can avoid long-term colchicine in this situation, it is always best. These situations (hypercholesterolemia and crystal arthropa...