Psychiatry
Expert discussions on psychopharmacology, behavioral health interventions, and psychiatric care approaches.
Recent Discussions
What medications do you recommend for a patient with ADHD and anxiety who becomes more anxious on a stimulant?
Consider non-stimulant ADHD medications such as atomoxetine and viloxazine. Although these are not as effective for nearly as many patients as the stimulants, they are a reasonable alternative and generally well tolerated. Despite the potential for bupropion to also cause a patient to feel more anx...
When do you recommend neuropsychological testing in adults being evaluated for ADHD?
We should consider “testing” only when our main tool of diagnosis, a thorough psychiatric interview, history, and physical (mental status exam), demands more data for a diagnosis. Demanding neuropsych testing would be akin to relying more on an MRI than on a clinical assessment for a headache diagno...
What is your approach to titration of sublingual cyclobenzaprine in your patients with fibromyalgia?
Follow the FDA instructions: start at 2.8 mg sublingually at bedtime for 14 days, if tolerating, then increase to 5.6 mg nightly starting day 15 onwards. Ensure the mouth is not too dry as saliva is needed for it to fully dissolve, which could take 2-3 mins. This may be a concern in patients with SI...
Which patients do you think would benefit most from xanomeline-tropsium (Cobenfy) monotherapy?
What we know best about this new drug, Cobenfy, a xanomeline-trospium combination, is that it does not directly affect the dopamine receptor, so it is novel and a new antipsychotic drug. And its antipsychotic efficacy has been demonstrated and accepted by the FDA. But still, we have a rather ‘pure’ ...
What is your approach when evaluating a child brought in by parents who suspect PANS/PANDAS as the cause of the child's psychiatric symptoms?
I encourage reading of the recent comprehensive review of all aspects of PANS in Pediatrics, This is a policy statement by the American Academy of Pediatrics. It is comprehensive and balanced, acknowledging key controversies in diagnostic and treatment approaches. In my clinical practice, the greate...
How do you approach patient requests for long-term disability for major depressive disorder?
There is the medical side to this question and the documentation. Incidentally, oftentimes if there is a forensic issue to the disability, it is very difficult for the disability to be resolved until the forensic piece has been resolved. Have you and the patient determined that disability is clearly...
How do you approach managing intolerable vivid dreams as a side effect of SSRIs?
Given that the dreams are described as intolerable, I would transition to an agent more favorable in terms of sleep architecture, such as vilazodone (Viibryd).
When and how do you approach prescribing viloxazine for patients with ADHD?
Viloxazine is a potent inhibitor of CYP1A2 and a weak inhibitor of CYP2D6 and CYP3A4. It should never be used within 2 weeks of an MAOI. I use significant caution when prescribing it with other psychotropic medications, as it can raise the levels of multiple other agents, including aripiprazole, dex...
How do you discuss lithium with patients who are hesitant due to concerns about side effects or monitoring requirements?
I inform patients that lithium is one of the oldest and most studied mood stabilizers. Many people do well on it for years with no or minimal side effects. Patients report that after years of suffering, it provides a sense of calm and helps with sleep. There is some evidence that it reduces suicide ...
How do you decide whether to request a welfare check (police or mobile crisis) when a typically responsive outpatient becomes suddenly unreachable?
Patient safety and welfare come first. If a patient suddenly becomes unreachable, a welfare check is in order. A reasonable person would comprehend that this is borne of concern and should not cause a breach in the therapeutic relationship. On the contrary, most would be grateful for the concern.