Rheumatology
Clinical discussions on autoimmune diseases, biologic therapies, vasculitis, and musculoskeletal conditions.
Recent Discussions
In patients with lupus nephritis on maintenance therapy, is there additional benefit in utilizing 2 grams vs 3 grams of mycophenolate mofetil (MMF) daily?
I agree with @Dr. First Last's answer. A few nuances to add: In my patients of African Ancestry, I always start with 1.5 gm bid if tolerated as they tend to need a higher dose (probably related to lower enterohepatic circulation, more rapid mycophenolic acid clearance, and other metabolic mechanism...
How do you treat sarcoidosis associated hypercalcemia in a patient with adenopathy and no other signs of systemic involvement?
This may seem like a straightforward query, but like many issues surrounding sarcoidosis, it is actually deceptively complex. For a more complete discussion, I refer the readers to an excellent review by Lower and Saidenberg-Kermanac’h (2019). In and of itself, asymptomatic “mild” hypercalcemia does...
Are there specific recreational activities or exercises you recommend patients with ankylosing spondylitis avoid?
The answer to this question depends on the severity of ankylosing spondylitis in the individual patient. The disease can manifest as sacroiliitis alone or total ankylosis from the sacrum to the cervical spine. The recommendations are different for those with limited disease versus extensive involvem...
Would you continue Rituximab infusions in a patient with GPA and renal involvement who has been in remission on Avacopan and Rituximab, but had PRES post Rituximab infusion?
PRES (Posterior reversible encephalopathy syndrome) is a potential complication reported with rituximab (RTX) use, not only in rheumatology but also in the oncology literature. It usually resolves, however, there are reports of potential mortality, and of course, morbidity while it is ongoing.If PRE...
Would you avoid radiation in a patient with breast cancer with active skin lupus?
In a patient with active skin lupus, I would counsel regarding the risks of radiation toxicity based on data available. Based on previous encounters, most patients after discussion of risks/benefits pursue mastectomy. If the patient still wanted to pursue BCT, I would discuss with their rheumatologi...
When would you use tocilizumab to treat Takayasu's?
Currently, systemic steroids are the mainstay of Takayasu treatment. Because of the chronic nature of TAK and steroid related side effects, I favor treatment with an additional immunosuppressive agent early on in the disease course. In the majority of patients, methotrexate is prescribed as the firs...
How would you manage a middle-aged patient with Paget's disease who received one dose of zolendronic acid 2 years ago, currently suppressed CTX, normal bone-specific Alkaline phos, and a recent hairline fracture in the thoracic spine?
Parathyroid hormone analogs are, of course, contraindicated in patients with Paget's disease and I am not aware of any data regarding the use of romosozumab in patients with this condition. Paget's disease is primarily considered to be an osteoclast-related disorder and bisphosphonates, particularly...
How would you approach treating a patient with active rheumatoid arthritis and a history of treated lymphoma that is currently in remission?
I would individualize treatment in each patient depending on degree of RA activity, type of lymphoma and length of time of remission with shared decision-making between myself, patient and oncologist. For moderate to high degree of activity of RA, in general, rituximab in keeping with the ACR 2021 g...
How do you approach patients with RA and severe bronchiectasis with associated findings of UIP?
Usual Interstitial Pneumonia or UIP is among the most serious forms of RA-associated lung disease. Clinical studies have demonstrated that its prognosis is similar to idiopathic pulmonary fibrosis (IPF). UIP is extremely challenging to treat and we have learned from experience that our DMARDs and bi...
When do you consider immunosuppression in patients with Sjogren's neuropathy?
Only when disease activity is moderate-severe, impairing QoL, or rapidly progressive, ie mononeuritis multiplex/vasculitis, with significant risk of end-organ/tissue damage. Occasionally, autonomic neuropathy in SjD can be so debilitating to patient, and all other supportive treatments have failed, ...