Rheumatology
Clinical discussions on autoimmune diseases, biologic therapies, vasculitis, and musculoskeletal conditions.
Recent Discussions
Is there a role for PCSK9 inhibitors in patients with statin-associated immune mediated necrotizing myopathy?
The majority of patients with statin-associated immune mediated necrotizing myopathy are in need of cholesterol-lowering medications. While one can try other strategies (like diet or ezetimibe), these are usually inadequate. Therefore, I would advocate for PCSK9 inhibitors as first-line treatment, w...
What is your approach to treating refractory thrombocytopenia in lupus?
Refractory thrombocytopenia is challenging to treat. It is important to evaluate for non-SLE causes including infection, medications, and malignancy. It is also important to differentiate ITP from TTP/atypical HUS. Once the ITP diagnosis is confirmed, I usually don't treat asymptomatic thrombocytop...
What do you use for treatment induction in pure class V lupus nephritis with nephrotic-range proteinuria when MMF is contraindicated?
I'll begin my response by commenting that other than an allergic reaction, which is very rare or pregnancy, there is really no absolute contraindication to MMF. On the other hand, there are patients who cannot tolerate MMF most often due to G.I. side effects in which case mycophenolic acid is an opt...
Are there particular concerns related to the use of B-cell depletion therapies such as rituximab for rheumatic disease during the COVID-19 pandemic?
The attendant depletion of CD20+ B cells associated with treatment with rituximab likely results in impaired development of host immunity to previously unrecognized microbial pathogens. This has, therefore, been of concern in the context of the Covid-19 pandemic due to potential greater adverse outc...
What is the biologic of choice in a patient with RA and history of non-melanoma skin cancer?
We have long known that patients treated with TNF inhibitors (TNFi) have a higher risk of developing non-melanoma skin cancers. For this reason, all patients prescribed these drugs should undergo annual full-body dermatology skin exams. If this recommendation is followed, there should be no contrain...
What are the benefits of sending HLA B27 genotype over HLA B27 antigen when evaluating for spondyloarthritis?
HLA-B27 is strongly associated with ankylosing spondylitis (AS) which is an inflammatory rheumatic disease that affects the spine, the sacroilliac joints, and peripheral joints. It is also associated with other diseases like acute anterior uveitis, inflammatory bowel disease, or psoriasis. HLA-B27 t...
How do you approach patients with overlapping features of PMR and seronegative RA?
To me, this is the same as saying how to treat large and small joint rheumatoid arthritis in the same patient. For me, the difference is largely in the use of steroids. I have used much less steroids in my patients who I believe to have small joint seronegative rheumatoid arthritis, initiating a DMA...
Are you recommending the mRNA COVID-19 vaccines to your patients with immune mediated inflammatory diseases?
This is THE question at the moment for providers of patients with immune mediated inflammatory diseases. For now, we are merely extrapolating as patients with active IMIDS were censored from trials (Pfizer & Moderna). Organizations like the American College of Rheumatology are moving quickly to clos...
What are specific treatment considerations for dactylitis- or enthesitis-predominant AxSpa/PsA?
Treating these manifestations of peripheral SpA is challenging. It is always important to have a baseline assessment of the liver and kidney function as well as other relevant labs prior to starting therapeutic treatments. In addition, careful assessment and consideration to comorbidities should be ...
How useful are anti-ribosomal P antibodies in the evaluation for SLE psychosis?
I do not think they are very useful at all. This may be a controversial opinion, but I think they should be largely retired from clinical practice. Though somewhat dated, an excellent meta analysis (Karassa et al., PMID 16385548) on this question concluded the following: "This meta-analysis demonstr...