Rheumatology

Adult-onset Still

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What is your approach to long-term immunosuppression in patients with Adult Onset Stills Disease?

How would you approach escalation of therapy in an adult patient with refractory Still’s disease and associated MAS/HLH (ferritin >100,000, transaminitis, DIC) despite high-dose steroids, high-dose anakinra, tocilizumab, and ruxolitinib?

Subsequently, emapalumab was initiated with a loading dose, followed by etoposide, which led to improvement in both symptoms and laboratory values. I...

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How do you approach management in patients with adult-onset Still’s disease presenting with active polyarthritis (without macrophage activation syndrome) who remain symptomatic despite prednisone 15 mg/day and methotrexate 25 mg/week?

What biologic therapy do you consider next?

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How do you approach management of Adult Onset Still's disease in a patient with ongoing fatigue and inflammatory joint pain despite methotrexate, colchicine, canakinumab and tocilizumab?

Heritable autoinflammatory gene testing negative. Is there a role for TNF inhibitor?

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Rheumatology

Adult-onset Still

Questions discussed in this category

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