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Urology

Urology

Expert guidance on urologic oncology, stone disease, BPH management, incontinence, and minimally invasive surgical approaches.

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Does a negative staging PSMA PET in a patient with biopsy-proven recurrent prostatic adenocarcinoma change your management?

2 Answers

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Radiation Oncology · University of British Columbia

The bottom line is that you have to believe the biopsy. PSMA PET will not show microscopic disease, which is why it cannot "rule out" disease in lymph nodes or elsewhere. It is comforting when it is negative, but it is not absolute truth. A few questions; What was the PSA at the time of the PSMA PET...

Do you recommend patients consume dairy products over taking calcium carbonate with meals if they have recurrent calcium based nephrolithiasis and persistent hyperoxaluria?

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Nephrology · Medical College of Wisconsin

I generally consider the decision between dairy and calcium tablets in the context of other medical conditions. For instance, if the patient has surgical or medical short gut syndrome as a cause of hyperoxaluria, I favor using calcium tablets to help compensate for the enteric loss of bicarbonate in...

Do you recommend checking 1,25-hydroxy vitamin D levels in patients with recurrent nephrolithiasis who have hypercalciuria of unknown etiology?

3 Answers

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Nephrology · Mayo Clinic

No, unless they are hypercalcemic or I suspect renal sarcoidosis. Stephen B Erickson, MD

Are there any factors which would lead you away from recommending active surveillance in low risk prostate cancer?

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Radiation Oncology · Brigham and Women's Hospital

A healthy male with a BrCa mutation Or Any male with at least 50% + bxs Or The presence of Perineural invasion Or PSA density more then 0.30 may be a new indication after the AUA this year Would prompt a mpMRI and then fusion bx of any PiRADS 3,4 or 5 areas to rule out grade 4 pc

Would you consider a patient with spina bifida and end stage kidney disease secondary to reflux nephritis with an ileal conduit for a kidney transplant?

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Nephrology · Mayo Clinic

In general, patients with ileal conduit and those with neobladder can be considered for kidney transplantation.

What is your approach for patients with recurrent nephrolithiasis who you have a strong suspicion for primary hyperoxaluria though genetic testing returns without any abnormalities?

1 Answers

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Nephrology · Mayo Clinic

As an adult nephrologist, most of my patients with oxalosis have enteric hyperoxaluria. I suggest you take a careful history, looking for inflammatory bowel disease, removal of small bowel or surgical rerouting of the intestines. If your patient is a child, I would explore the possibility of insuran...

How would you approach treatment for a cT1N0M0 urothelial carcinoma of the ureter, high grade in a non-surgical candidate due to medical comorbidities?

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Medical Oncology · University of North Carolina at Chapel Hill

Although there is limited data using radiation therapy or chemo-radiation in UTUC, in a non-surgical candidate, this may be a reasonable approach to consider in selected patients. This would be an extrapolation from the promising data from RTOG 0926, a single arm, phase II trial investigating trimod...

Is it unusual to have isolated LDH elevation and normal HCG and AFP in non-seminomatous germ cell tumor (embryonal carcinoma)?

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Medical Oncology · Cleveland Clinic

It's hard to generalize: the details of the case matter. It is not very unusual to have an isolated LDH elevation. LDH is extremely non-specific. 101 different things can make LDH go up and this limits its usefulness as a tumor marker. Elevation of LDH on day 1 of cycle one of first-line chemotherap...

Do you recommend dietary changes to your patients with recurrent kidney stone disease who consume coffee and low oxalate teas daily?

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3 Answers

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Nephrology · Mayo Clinic

Thank you for your question. Many patients get tired of drinking water and would prefer coffee, low-oxalate tea, or other beverages instead. Studies have shown no difference in whether the water is hard or soft. Coffee and low oxalate tea do not seem to increase stone passage either. There is some d...

Why do the most recent NCCN guidelines (Version 4.2024, 05/17/24) omit the duration of ADT for high-risk prostate cancer patients?

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Radiation Oncology · Associated Medical Professionals

No idea, but version 1.2025 (accessed 12/10/2024) now includes ADT duration for high-risk, which is 12-36 months, with notes indicating, "For high-risk and very-high-risk prostate cancer treated with combination EBRT brachytherapy, a shortened duration of ADT (12 months) can be considered." For high...