Could patients with smIPI > 1 and poor tolerability to RCHOP be offered ISRT after 3 cycles of RCHOP if interim PET showed 5-PS 1-3 response?

The FLYER and LYSA/GOELAMS studies have significantly influenced the management of DLBCL. Although the studies were quite different, they both demonstrated that patients with non-bulky, stage I-II DLBCL and a favorable IPI do very well with 4 cycles of R-CHOP alone. For patients with 0 or 1 stage-mo...