Do more fractionated regimens reduce severe toxicity over SBRT in patients with ILD and early-stage NSCLC?

I personally think fewer fractions are safer, such as 30 Gy x 1 instead of 10 Gy x 5, for patients with advanced COPD or ILD. Why? It's because each time a burst of ionization events is delivered to pulmonary tissues, a wound is created that recruits an inflammatory response, which can exacerbate th...

We attempted to address the question of fractionation and dose in relation to lung function. Our study, published in the International Journal of Radiation Oncology, Biology, and Physics (Vol. 11, p. 528) and the British Journal of Cancer (Vol. 55, Suppl VII, pp. 324-326), involved using single, fra...

I've come to bet on single-fraction lung SBRT for these patients and have yet to see a complication. I generally deliver 25 Gy for subsolid and 30 Gy for solid tumors. I always use some sort of motion mgt strategy for these high-risk cases and won't treat them with uncontrolled free-breathing IGTV t...