New: NCI-funded clinical trial search
Mednet Logo

Over what time frame do EMG/NCS of AIDP patients normalize?

If the EMG/NCS normalizes too early, are you concerned about the accuracy of the initial diagnosis?
1 Answer
Mednet MemberInvited Expert
Neurology · University of Minnesota
Answered on

Answering this question is complicated due to the concept of reversible conduction failure in GBS. This concept was introduced by Kuwabara in 1998 (1) and it describes a subset of patients who often had preceding diarrheal illness from Campylobacter and very high GM1-IgG antibody titers, who would normally be classified as acute motor axonal neuropathy (AMAN), yet they exhibit unusual electrophysiologic and clinical features. They recover extremely quickly, within 4-6 weeks (which would not be expected with severe axonal injury causing Wallerian degeneration of nerves), and their EMG/NCS will also normalize within the same interval. The initial NCS in those patients will often show what looks like motor conduction block, which goes away wit...

Join for free or sign in to see the full answer