Do TTFields work synergistically with SRS for patients with brain metastases?

This question is part of our collaboration with ASTRO 2025 to highlight impactful trial data from this year's meeting. This question is inspired by the Plenary Session Presentation "Tumor Treating Fields (TTFields) After Stereotactic Radiosurgery (SRS) for Brain Metastases from Non-Small Cell Lung Cancer (NSCLC BM): Final Results of The Phase 3 METIS Trial" by Dr. Vinai Gondi.

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Radiation Oncology · Harvard Medical School

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Based on the presented data from the METIS trial, yes, TTFields works synergistically with SRS for patients with NSCLC brain metastases. It is not clear on the mechanism of action. It appears there is even greater synergy with use of ICI. One hypothesis is whether there is enhanced immune response, ...

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Radiation Oncology · Florida International University

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In terms of the synergy of TTFields with radiation, we have little direct data for confirmatory validation of this interaction. However, there are some limited data that suggest that there is synergy between TTFields and several other therapeutic modalities, including chemotherapy and radiotherapy...

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Radiation Oncology · Cleveland Clinic

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Dr. @Dr. First Last presented as the discussant, the rationale for synergism with ICI. The improvement in local control seen does imply synergism with SRS, as Dr. @Dr. First Last mentioned.

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