Several studies in the metastatic setting (e.g. the TNT trial) have suggested an improved response and progression free survival with platinums in BRCA –mutant breast cancer. In the neoadjuvant setting, a study of 107 women with breast cancer and BRCA1 mutation, treated with 4 cycles of cispla...

Although the data right now are somewhat mixed for adding platinum to neoadjuvant chemotherapy for TNBC, I am impressed by the TNT trial comparing carboplatin to docetaxel in the subgroup of metastatic BRCA associated cancers. I usually use AC x 4 (q3w) followed by paclitaxel weekly x 12, and add ca...