Do you add chemotherapy to pelvic radiation and brachytherapy for an isolated vaginal cuff recurrence of endometrial cancer?

We offer concurrent cisplatinum with EBRT to high grade or bulky vaginal disease

https://www.ncbi.nlm.nih.gov/pubmed/25241996

We offer enrollment to the current NRG trial which randomizes to RT plus or minus sensitizing platinum chemotherapy. Off of trial, I having been treating with RT alone.

I agree with Dr Kharofa that enrolling patients to GOG-0238 is the right thing to do providing that one has this protocol open in their institution.

Off protocol, we tailor our approach according to the extent of disease at recurrence. Patients who have a recurrence found on a smear but no evidence of gross disease or vaginal vault recurrence of small volume (1 cm or less) are treated with pelvic radiation and brachytherapy only. If on pelvic MRI and physical examination the residual disease is less than .5 cm at the time of brachytherapy we will use endocavitary brachytherapy if not, will consider interstitial.

For patients with more bulky disease, we tend to proceed with chemo-radiation, using weekly cisplatin and complete treatment with...