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Do you always perform salivary gland biopsy to confirm the diagnosis In patients with suspected seronegative Sjogren's syndrome?
Answer from: at Community Practice
I often struggle with the decision of obtaining a biopsy in suspected Sjogren's in a person who is seronegative, when the main issue is dryness, and the main reason is that I wonder if it will make a difference in management.
When I was a Rheumatology fellow, I was taught to give Hydroxychloroquine...
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Answer from: at Community Practice
No, but MSGB (minor salivary gland biopsy) can provide useful information, in addition to supporting the clinical diagnosis of Sjogren's disease (SjD), if the Focus Score is 3-4 or greater, the risk of lymphoma development is higher.
For patients, if they are SSA/SSB negative, they often report hav...