Do you always start treatment for patients who meet diagnostic criteria for multiple myeloma by SLiM criteria alone?

No, I definitely do not always start treatment for patients who meet the so-called myeloma defining events. These are guidelines, like the Pirate Code.

Sixty percent plasma cells mean reaching CRAB criteria in 2 years in 95% of patients, greater than one 5 mm MRI abnormality means CRAB criteria in 7...

I agree with @Dr. First Last - the expanded diagnostic criteria have no direct clinical impact and do not carry quite the same weight as the classic CRAB criteria. I have several elderly patients whose light chain ratios surpassed 100, and who after a balanced discussion opted to defer treatment. Th...