Do you avoid dupilumab (IL-4 inhibition) for severe asthma in patients already taking a biologic agent for RA?
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Do you feel comfortable combining dupilumab with a biologic used to treat rheumatic disease?
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1 Answer
Mednet MemberInvited Expert
Rheumatology · Harvard Medical School
Answered on
Dupixent (dupilumab) is a humanized monoclonal IgG4 antibody that works by blocking the signaling of interleukin-4 (IL-4) and interleukin-13 (IL-13). This is achieved by binding to the IL-4Rα subunit. When dupilumab occupies this subunit, it prevents IL-4 signaling via the Type I receptor and both I...
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