Do you check IgA levels before starting IVIG for other autoimmune conditions?

Whereas it is not mandatory to check IgA levels before starting IVIG, it is prudent to do so in non-urgent situations since the patients with IgA deficiency, especially those who have developed anti-IgA antibodies, are at an increased risk of severe hypersensitivity or anaphylactic reactions from IV...

Patients with low IgA levels are at high risk for developing severe allergic reactions. In these patients, IVIG with low IgA levels can be considered as an alternative.

Yes - I would check IgA levels as those with IgA deficiency are more likely to develop antibodies to IgA and should be prescribed a low IgA IVIG or SQ IgG formulation to decrease potentially severe allergic reactions.