Do you choose an antibiotic with CSF penetration, such as nafcillin over cefazolin, in the setting of MSSA endocarditis with septic emboli to the brain (assuming no concomitant meningitis or brain abscess)?
Answer from: at Academic Institution
I have started using cefazolin in such instances, guided by existing data indicating reasonable CNS penetration. I will administer a higher dosage of 2 gm IV every 6 hours. I have observed a case where septic emboli progressed to an MSSA brain abscess despite treatment with cefazolin 2 gm IV every 8...
Sign in or Register to read more
Answer from: at Community Practice
Yes, Ancef is well tolerated than nafcillin.