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Do you consider MSI testing for nonserous ovarian cancer?

1 Answer
Mednet MemberInvited Expert
Gynecologic Oncology · Cooper Medical School of Rowan University
Answered on

I do, but with the understanding that PD1/PDL1 expression, MSI/MMR is less well documented than in high grade serous cancers. Meagher et al has a nice article in Gyn Oncol 2018 looking at molecular profiling in 333 mucinous lesions. Common mutations noted were KRAS (60%), TP53 (38%), and HER2 in up to 13%. Trametinib may be an option for patients with particular KRAS mutations, and certainly trastuzumab may be an option for those with HER2 overexpression.

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