Would you consider the use of prophylactic antibiotics in patients admitted with decompensated cirrhosis with AKI with Cr>1.2, with ascitic fluid protein <1.5 without SBP and/or hyponatremia/Bili >3?

Is this in generalized cases or cases of GIB? If GIB, yes, I would consider it. In just generalized cases, there is no real role for empiric antibiotics.

I would treat empirically pending results of ascitic fluid PMN count AND culture results, especially if the patient did not look well and there was no clear reason for the decompensation. Another reason would be possible GI bleeding.