Topics:
Gastrointestinal Cancers • Medical Oncology
Do you consider using capecitabine and irinotecan (XELIRI) instead of FOLFIRI for first line metastatic colorectal cancer?
Answer from: Medical Oncologist at Academic Institution
There are no data to suggest that CAPIRI is more effective than FOLFIRI. However, the former is a much more toxic regimen, primarily because diarrhea is a significant, overlapping toxicity with capecitabine and irinotecan (BICC-C trial, JCO 2007). Consequently, I don't use CAPIRI.
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